Building a world-leading cooperative research and education program in Oncological Data and Computational Scienceto accelerate progress against cancer
The University of Texas MD Anderson Cancer Research Center, The Texas Advanced Computing Center (TACC) and the Oden Institute are collaborating in oncological data and computational science research. The strategic initiative creates a unique opportunity to align mathematical modeling and advanced computing methods with oncology expertise to bring forward new approaches that can improve outcomes for patients with unmet needs. Bringing together MD Anderson’s oncology expertise and data with novel mechanism-based computational modeling and data science techniques led by researchers at the Oden Institute and TACC, this partnership supports not just cancer research but also the training and development of teams that will lead computational oncology research into the future.
The following nine active seed projects bring together researchers from seven different units at UT Austin and six different departments at MD Anderson.
Rapid, motion-robust MRI for fast and affordable prostate cancer screening and surveillance
Ken-Pin Hwang of MD Anderson’s Department of Imaging Physics and Jon Tamir of UT Austin’s Department of Electrical and Computer Engineering and the Oden Institute will use mathematical modeling and massively parallel distributed computing to make prostate MR imaging faster and more accurate to reduce the incidence of unnecessary or inaccurate biopsies.
Particle/Proton therapy translational research platform
Xiaodong Zhang of MD Anderson’s Department of Radiation Oncology and Hang Liu of TACC will advance both the planning and delivery of proton therapy via a platform that combines mathematical algorithms and high-performance computing to further personalize these already highly-tailored treatments.
Personalization of glioma treatment via imaging-informed mechanistic-models of tumor progression
Caroline Chung of MD Anderson’s Department of Radiation Oncology and David Hormuth of the Oden Institute’s Center for Computational Oncology are using computational models of the underlying biology to fundamentally change how radiotherapy and chemotherapy is personalized to improve survival rates for brain cancer patients.
Forecasting treatment response to neoadjuvant systemic therapy in triple negative breast cancer for personalized medicine via mathematical modeling and quantitative MRI
Angela Jarrett of the Oden Institute’s Center for Computational Oncology and Maia Rauch of MD Anderson’s Department of Abdominal Imaging will develop a patient-specific mathematical model for forecasting treatment response and designing optimal therapy strategies for patients with triple-negative breast cancer.
A mechanistic tumor growth model for HP MRI
Prashant Jha and J. Tinsley Oden of the Oden Institute’s Center for Computational Oncology and David Fuentes of MD Anderson’s Department of Imaging Physics will integrate a new mechanistic model of tumor growth with an advanced form of MRI to reveal underlying metabolic alterations in tumors and lead to new treatments for patients.
Characterization of thermoembolization cellular damage with computational modeling
Nichole Rylander, UT Austin’s Department of Mechanical Engineering and the Oden Institute’s Center for Computational Oncology; David Fuentes, MD Anderson’s Department of Imaging Physics; Erik Cressman, MD Anderson’s Department of Interventional Radiology.
Development of advanced machine (deep) learning algorithms to rapidly detect and accurately estimate the percentage of melanocytes expressing Mart1-Ki67 in borderline melanocytic lesions, and PDL1 in tumor cells, using double staining with tumor specific markers
Chandrajit Bajaj, UT Austin’s Department of Computer Science and the Oden Institute’s Center for Computational Visualization; Phyu P. Aung, MD Anderson’s Department of Pathology.
Establishing a single-cell spatial multi-omics reference atlas for studying human hematopoietic malignancy
Song (Stephen) Yi, UT Austin’s Department of Biomedical Engineering and the Oden Institute; Ken Chen, MD Anderson’s Department of Bioinformatics and Computational Biology.
Patient-specific computational models to forecast prostate cancer growth
Thomas J. R. Hughes, UT Austin’s Department of Aerospace Engineering and Engineering Mechanics and the Oden Institute’s Computational Mechanics Group; Aradhana M. Venkatesan, MD Anderson’s Department of Abdominal Imaging.
Learn more about our research in computational medicine.