Past Event: Oden Institute Seminar

Patient Specific Model of Left Ventricle with Mitral Valve: Insight of Ischemic Regurgitation Following by Myocardial Infarction. ** Day and Time has changed**

Hao Liu, PhD student, Willerson Center for Cardiovascular Modeling and Simulation, UT Austin

Abstract

The mitral valve (MV) regulates blood flow from left atrium (LA) into the left ventricle (LV). Ischemic mitral regurgitation (IMR) occurs when the mitral valve (MV) is rendered incompetent by left ventricular remodeling induced by a myocardial infarction (MI). This dysfunction is manifested by the inability of the MV (which consists of the valve leaflets, annulus and chordae tendineae), which subsequently leads to abnormal blood flow from the left ventricle back into the upper left atrial chamber, and hence abnormal cardiac performance. There is now agreement that adjunctive procedures are required to treat IMR, yet there is no consensus regarding the best procedure. In this study, we present a pipeline that allows for patient-specific modeling of lv-mv to predict the valvular response to annuloplasty repair and with high predictive power and onset of ischemic regurgitation followed by myocardial infarction. Our framework only relies on the clinically obtainable imaging data prior to the MV repair operation and thus can be extended into a virtual surgery tool that provides surgeons with additional insight into the patient-specific valvular response to different treatment options. Bio: Hao Liu is a 3rd year PhD student in the Willerson Center for Cardiovascular Modeling and Simulation, supervised by Dr. Michael Sacks.